![]() There are many Mailing Services companies that have an established track record and reputation, so it is important to go with a service that is known for its expertise. Mailing Services can help your small business get started quickly, and they will help you maintain a high-volume mailing list once your business is established and running smoothly. There is no point in using Mailing Services if it is not going to give you the greatest value for your money. The costs associated with Mailing Services are all relative, and your goal is to find the most cost-effective solution for your specific circumstances. Mailing Services does not have to be extremely expensive. Certain companies provide services such as direct mail remarketing Atlanta where you can use addresses to send other promotions. Also, there is an option called remarketing. ![]() Mailing Services can be tailored to any size of business, and they can get started immediately after you have completed your survey. You can use the USPS software to determine the rates that you charge, and the rates that you will get for bulk mailing envelopes, which means that you can set your pricing at any level you choose. If you use a USPS service, you will be able to easily choose which addresses will appear on your bulk mailing envelope, and you will also get started customizing it to fit any particular campaign that you are launching. The next part of Mailing Services is easy. For your small business, this could be done as an add-on service when you start with your Mailing Services, which is the most logical choice. Once you have a company in place, your next step will be setting up an account. Next, you need to determine your budget so you know exactly how much you can spend on each aspect of your bulk mailing service. The first step into marketing is to find a company to supply you with Mailing Services. These business owners are now looking to contract with companies to provide these services to them. This does not include telemarketing, but rather the mailing services. Over 90 percent of the responding entities stated that offering these services either largely increased sales from existing clients (40%) or brought in new clients and added revenue from new clients. In general, offering online bulk mail services is viewed as a very good means to generate extra income even without having to develop new clients. A growing number of business owners are looking for Mailing Services.
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![]() In cases similar to ours, we believe that it is one of the best options and that in the long run it will pay off, especially due to the fact that it is a single payment that does not require after subscriptions. ![]() In our case we have already commented that daily for professional reasons we dedicate ourselves to visiting numerous websites in languages other than our own, so it is a very useful and complete tool with which we get a great experience. Of what? Well, basically about you and your use of the Mac. Like almost everything in life, it depends. The application knows how to detect very well the way in which each language is expressed and translate it in an understandable way, so in this section, which is ultimately the most important, we can be more than satisfied. Luckily, we have never come across one of those translations that seem to speak in Indian or translate everything literally. He is still a translator who in the end will never show a one hundred percent natural language, but is at the level of other great translators. However, taking into account the most common languages such as English, we can give it a very high grade in this regard. Unfortunately at this writing we are not polyglot enough to thoroughly analyze the level of translation of Mate Translate in each and every one of the languages in which it is available. Spanish, English, French, German or Chinese are among them, these being the most popular, but they are not the only ones as we have previously commented when mentioning the large number of languages that Mate Translate understands. Up to 103 languages are available in this application, so you will hardly come across a language that is not accepted. Then we find another series of very useful settings also in relation to how it works when starting the Mac or choosing to translate in Safari with a double click. ![]() Although by default it is Option / Alt Shift + T, we can change it to any other that is more comfortable for us. The first thing we observe when going to the settings of this application is a keyboard shortcut that will be great to know to be able to open it at any time. It even has the possibility of listening to the pronunciation if we press the speaker icon. If at any time we want to translate a text that we have in mind or that we copy directly from somewhere, we can easily do so by going to the corresponding icon of the application. The other great star functionality of Mate Translate is to be able to access the translator at any time thanks to its integration in the upper menu bar of the screen. The translation appears in a small pop-up speech bubble that doesn’t make it intrusive. The way to do it is by means of the normal selection of the text, doing secondary click with the mouse or trackpad and choosing the option of Mate Translate. This is tremendously useful on occasions when we do not need to translate the entire page because either we already master the language and we miss a word or phrase or because we are simply learning that language. Where the application draws our attention the most is the possibility of translating a single word or certain selection of text on a web page. Although if we take into account that since macOS Big Sur we already have a native translator in Safari, the truth is that Mate Translate goes to the background in this sense. Obviously the translation of Safari web pages is one of the most prominent and it works very well. As far as possible, we are fortunate that if you buy it on iPhone you will have it on iPad and vice versa, but it would be tremendously positive if the developer allowed a single payment to be made for having the application available on all computers.Īnalyzing now the application as such and its operation, it must be said that it is an all-terrain tool because it is functional in many places in the system. It has a price in these systems of 16.99 euros. Of course, we find a clear disadvantage in this regard and that is that you will have to pay it again even if you have bought it on the Mac before and vice versa. However, we believe that this is worth mentioning and that is that you can also download it on your iPhone or iPad having functionalities adapted to their operating systems. Perhaps this section would be worthy of analysis in a different article, since we are focusing on Mate Translate for Mac. There is also a version on iOS and iPadOS ![]() They are not well adapted to a warm, dry atmosphere and must be kept moist and in a cool position, preferably in the dark. If you do not maintain a colony of woodlice in the laboratory, collect woodlice from an outdoor environment, keep for a short period and return them to their source as soon as possible. This will provide a source of material for observation as well as extending the range of microhabitats in the area. Where your school has an environmental area, placing pieces of wood, bark or stone on the soil will encourage colonisation by woodlice. Add a lump of cuttlefish or chalk (natural, not blackboard chalk) to the soil to provide a supply of calcium carbonate. If this does not happen, or the animals are intended for use in choice-chamber work, it is worth ‘seeding’ it with individuals of the same species – the animals should look the same! Then bring the container and contents indoors to prevent further colonisation.Īdd food at intervals: plant material such as potato, carrot and other root vegetables cut up into medium-sized pieces. If kept outdoors, such an environment will often be colonised by woodlice naturally. Put a variety of stones, bark and rotting wood on the soil for the woodlice to live in. Place it in a relatively cool and sheltered place out of direct sunlight. Keep the container covered to exclude light and retain moisture. They survive in any reasonably-sized container such as an old aquarium or trough full of moist soil and leaf litter. Collect and transfer them using pooters or small artists brushes.Ģ Woodlice: the CLEAPSS Guide L56 'Housing and keeping animals' gives the following information about woodlice. Distribute beetles in Petri dishes or specimen tubes. Sieve the beetles from the flour before the investigation starts. You can rear them easily in a jar of wholemeal flour. Either species of Tribolium is suitable for these investigations. confusum and is therefore not such an important pest in temperate climates. It needs a higher temperature to complete its lifecycle than T. Tribolium castaneum (the red rust flour beetle) is commonly used in the laboratory. Tribolium confusum is probably the most common flour beetle in mills and bakeries. Read our standard health & safety guidanceġ Tribolium: Tribolium is a small flour beetle that attacks cereals and cereal products and is a pest of stored food. Explain the statistical test and analyse the data, possibly in the next lesson. Run the investigation and collect the data. Ask students to develop a hypothesis to test – relating to damp/dry conditions, light/dark conditions or the presence/absence of another manageable substance (such as the animal’s main foodstuff). Students practise manipulating the apparatus and handling the invertebrates appropriately. Lesson organisationĭemonstrate how to set up the choice chamber and how to introduce invertebrates to it. If the adjacent area is preferred, the animal reacts by reducing speed of movement and turning rate so it is more likely to stay in the preferred conditions. These may result in overall movement out of one area into another. You can state that woodlice do have a preference for one set of conditions over another.Īnimal behaviours in choice chambers may show directional responses (movement directly towards or away from particular stimuli), or may show behaviours such as increasing speed and increase in turning rate. Use a test such as the X 2 significance test to establish whether the final result is significantly different from the expected distribution. After a fixed time, compare the difference between the distribution you would expect if the null hypothesis were true (woodlice distributed 50:50 between damp and dry areas) and the distribution achieved in the laboratory. For example, a null hypothesis might state 'Woodlice show an equal preference for damp and dry areas in the choice chamber'. ![]() Investigations using a choice chamber often depend on developing a null hypothesis with which the final result is compared. You can then introduce small invertebrate organisms into the chamber, at different starting points, observe their movements, and record their distribution after a fixed time. These notes explain how a choice chamber is set up, and how to use one to provide adjacent environments with different environmental conditions. ![]() Security services in the capital of Moscow announced last week that they were closing Red Square to the public for an unprecedented two weeks in preparation for the military parade where Putin is expected to make an appearance.īaza, a Russian media outlet with sources in the security services, reported that the Russian ministry of defence was considering cancelling the aerial segment of the parade in both Moscow and St Petersburg, citing security concerns and a lack of trained pilots. Ukraine has previously used drones to strike deep inside Russian territory, in one instance hitting an airbase near Ryazan, a city just 150 miles from Moscow. ![]() There are signs that the authorities are also worried over drone attacks on its two biggest cities, Moscow and St Petersburg. “Of course, we are aware that the Kyiv regime, which is behind a number of such attacks, terrorist acts, plans to continue its line,” Peskov said when asked by reporters if there was a threat of Ukrainian attacks on the 9 May. 8.1.0 fails to connect to FTP-SSL (Explicit Auth TLS) server, 8.0.2 and Filezilla work Issue 12589 iterate-ch/cyberduck GitHub iterate-ch / cyberduck Public Notifications Fork 246 Star 2. Speaking to journalists on Tuesday, Putin’s spokesperson Dmitry Peskov stressed that the security services were “doing everything necessary to ensure security” on Victory Day. We use Google reCaptcha to protect our website and the Google Privacy Policy and Terms of Service apply. For more information see our Privacy Policy. Privacy Notice: Newsletters may contain info about charities, online ads, and content funded by outside parties. A Ukrainian drone strike last week set ablaze a Russian fuel storage facility in the Crimean port of Sevastopol. Russia has sustained a number of embarrassing incidents and attacks at its military bases over the course of the fighting, including in occupied Crimea. The cancellations came as Kyiv was making its final preparations for its much-anticipated counteroffensive. “Victory will be ours, like in 1945,” Putin said at the time. Last year during a speech, Putin said that the present-day Russian army was fighting in Ukraine “so that there is no place in the world for butchers, murderers and Nazis.” Moscow’s invasion of Ukraine has further shifted the meaning of the celebration as Putin has sought to draw baseless historical parallels between the two wars, falsely framing Ukraine as a successor to Nazi Germany. The carefully orchestrated victory parades that take place across the country traditionally present the Kremlin with an opportunity to flaunt modern Russian military might. Victory Day, when Russians celebrate the 1945 endpoint of what they call the “great patriotic war”, has gradually become the centrepiece of Vladimir Putin’s vision of Russian identity over his two decades in charge. NET Framework 4.8 maximum, as there is currently no way of getting IKVM to run on anything other than. Supported Protocols Īll major server and cloud storage protocols are supported to connect to just about any server or cloud storage.At least six Russian regions have cancelled their 9 May Victory Day parades Command Line Interface Ĭommand Line Interface (CLI) for Mac, Windows & Linux. Encryption for data at rest prevents unauthorized access regardless of the server or cloud storage infrastructure. Transparent, client-side encryption to secure your data on any server or cloud storage. Support for client side encryption with Cryptomator interoperable vaults. As a contributor you receive a registration key that disables the donation prompt. If you have this problem: Make sure youre using the. Mountain Duck lets you mount server and cloud storage as a disk in Finder on macOS and the File Explorer on Windows with a minimal User Interface and Smart Synchronisation feature that allows making files available offline. Cyberduck is free software, but it still costs money to write, support, and distribute it. An interoperability failure with Cyberduck usually means there is some type of network or firewall issue. ![]() Read more about system requirements, registration keys and incompatibilities. With an easy-to-use interface, connect to servers, enterprise file sharing, and cloud storage. The pages below has all the information on how to collect relevant log files.Ĭyberduck is a libre server and cloud storage browser for Mac and Windows. If you have a feature request or bug to report you can open a new ticket. ![]() And, based on how well it still runs at age 20, I expect it’ll be with us for many more years, hopefully making new generations of riders say “awesome.” It’s one of the best B&M floorless coasters out there. While it might not be the signature coaster at the park any more with Joker opening in 2016, it remains an “multi-ride” coaster for me any time I visit. It was also a pretty big deal for the Six Flags Marine World, firmly establishing it as a rival to nearby California’s Great America, and marking the height the mini-coaster war between the two parks (which we’ll get to more later on in our series). The giant vertical loop is fantastic, the ride is well paced with constant back to back elements, and, like with most modern B&M coasters, it’s consistently smooth. The drop immediately rises into the giant vertical loop, followed by a dive loop, reversing the trains direction back towards the station.įor such an element filled ride, that was so highly reviewed on its opening, I’m often surprised Medusa doesn’t get talked about much. Thanks to a small trench cut in the parking lot below, the coaster drops a full 150 feet. The ride itself sadly suffers from being a bit of a parking lot coaster, but at least the entry is good! From the station the trains climb the imposing hill to 150 feet, then dipping into the signature B&M “pre-drop”. The Medusa station is actually surprisingly well themed for an average Six Flags coaster, with good rock work and foliage around the entrance. While Roar was a great addition to the park in 1999, Medusa suddenly gave the park one of the biggest coasters on the West Coast, and some of B&M’s best work at the time. And while it was only the second coaster in California to feature 7 inversions, it’s safe to say Medusa’s are a bit more pleasant than the ones on Viper at Magic Mountain. It became the second longest B&M coaster in California, just behind Riddler’s Revenge at Six Flags Magic Mountain (but had a longer drop than Riddler’s). For Northern California, Medusa set a new standard for length and height, topping anything at rival NorCal park, California’s Great America. ![]() Plus, it had the first ever “Sea Serpent roll” on a B&M roller coaster. Medusa also featured the tallest vertical loop in the world when it opened, at 128 feet. ![]() Feel free to enjoy the modified features in Hotspot Shield with powerful VPN experiences. Download for Windows Download for Linux (Coming Soon) Awards for mHotspot. Moreover, it can be used by anyone since you are mostly required to press a button in order to connect. Last but not least, for those of you who’re interested in enjoying the completely free and unlocked VPN services in Hotspot Shield, you can now download and install the full version of the app on our website. Free software to use your windows computer/laptop as virtual wifi router and create a free wifi hotspot. Its powerful algorithm makes it virtually impossible for anyone to trace you. Hotspot Shield let us surf the web for free with our 500 MB daily data limit. Hotspot Shield VPN powered by Pango Pango. Not all free VPNs are worth the download. Hotspot Shield sets the ground for a stress-free anonymous browsing experience. Any unused portion of a free trial period, if offered, will be forfeited when the user purchases a subscription. The Settings window allows you to configure the level of protection for the Network Detection feature: you can set it to warn you each time your computer connects to new networks, to auto-connect to unknown networks or to turn off both of these options. Configure connections and protection levelĪfter years of lacking a desktop GUI, Hotspot Shield now comes with an interface from here, users now have a more clear option to connect or disconnect the VPN service. Hotspot Shield VPN Free Proxy Unblock Sites (Chrome Extens. The installation procedure is rather straightforward and Hotspot Shield remains very friendly with computer resources all the time, which means you should be able to run it on older machines as well. Hotspot Shield VPN Free Proxy Unblock Sites (Chrome Extension), free and safe download. With it, you can access web content without censorship and all of your video or voice chats are protected. Your personal details are kept invisible to third party ISPs (Internet service providers) and websites and all transactions are secured through HTTPS (Hypertext Transfer Protocol Secure) encryption. Hotspot Shield is a reliable choice if you wish to remain anonymous during your online sessions. In order to ensure complete anonymity, the application hides your IP address and arranges for you to remain protected as you travel to different Wi-Fi locations. Download 26mb free Pros Free version available A kill switch feature available to instantly disconnect the PC from the web Safe and secure VPN options available Built-in speed test feature Cons The free version will not be enough for most people as it is limited to 500MB per day In today’s technological world, privacy is a big question mark. ![]() ![]() It is equipped with a strong encryption technology (SSL) that allows it to secure web sessions, personal information and data transfers. Hotspot Shield is a VPN based software that acts as a shield against network and Internet surveillance. Note: Credit card activation is required for the free trial of 7 days. ![]() Reach legendary status as you rise through 8 divisions and compete in more than 10 cup competitionsīuild your soccer empire from your own Stadium to Medical, Commercial and Training facilities Work your way through the ranks to prove your team is the greatest and compete in Global Leaderboards for exclusive prizes!īuild and develop your dream team from over 3,500 FIFPro licensed playersįull 3D motion-captured kicks, tackles, celebrations and goalkeeper saves gives unmatched realism Along with our new and improved graphics engine, your dream team has never looked this good!ĭream League Online mode puts your club against the very best in the world. Dream League Soccer 2020 is the perfect soccer package, one which captures the true spirit of the beautiful game.įeast your eyes on the best-looking Dream League Soccer experience ever! Customise your manager from a host of different options including hairstyles and outfits. The very best Dream League Soccer experience awaits with new animations and improved AI weve revolutionised the most engaging football experience on mobile. Upgrade your stadium with world-class facilities as you make your way to the Legendary Division. Sign top superstar players such as Luis Suarez & Gareth Bale to create your very own Dream Team! Perfect your style, develop your players and take on any team who stands in your way as you rise through the ranks. The beautiful game has never been so good! There isn’t much in it from a technical perspective, however.Dream League Soccer 2020 puts you in the heart of the action with a fresh look and brand new features! Build your dream team from over 3,500 FIFPro licensed players and take to the field against the worlds best soccer clubs! Rise through 8 divisions whilst enjoying full 3D motion-captured player moves, immersive in-game commentary, team customisations and much more. There are other much-loved games of the same ilk including Underworld Football Manager, Soccer Manager, Hattrick and more. Based on popularity alone, the number one game would have to be PES (Pro Evolution Soccer). There’s a lot of competition for the top spot of football manager games. If you are using your iPhone, this means you will need to use the 5S model or higher. It can also be play on Apple devices such as iPhones and iPads. You can play Dream League Soccer 2020 on any Android device which uses Android 4.0.3 and up. The truth is, not a huge amount has change but that’s no bad thing and for a one year update I think it exceeds expectations. The game has also been kept up-to-date with the latest footballers and some of the old bugs are now a thing of the past. ![]() Everything feels much more real and the gameplay is smoother. The biggest difference between DLS 2019 and DLS 2020 comes in the graphics update. Connect with players around the world and submit your high scores to the Google Play leaderboards. You can still make numerous customizations to most aspects of your team (the name, the shirts, the stadium, etc.). ![]() There are still lots of divisions (6 in total) and cup competitions (7) to work your way through. If you know anything about football, you will recognize some of the players such as Cristiano Ronald, Gareth Bale, Lionel Messi, Sergio Aguero and more. It still has many of the tried and tested features including their FIFPro licensed players but now with over 3,500 players. Dream League Soccer 2020 has a long list of features. It is the details which separate games in this genre. The broad strokes of the game are appealing, but not necessarily original or new. You don’t need to be a soccer fan to enjoy Dream League Soccer 2020 Dream League Soccer 2020 has had a graphics makeover ![]() OTHER LOCATIONS: If you want to find out the timings of locations mentioned other than the above, then click here. Discover which options are the fastest to get your customer service issues resolved. ![]() ADDRESS: 1300 Guadalupe St., Laredo, TX 78040 Week DaysĪDDRESS: 1002 Matamoros St., Laredo, TX 78040 Week DaysĪDDRESS: 10700 McPherson Rd., Laredo, TX 78040 Week DaysĪDDRESS: 1000 Zaragoza St., Laredo, TX 78040 Week Days You can try any of the methods below to contact IBC Bank. These timings are subject to change depending upon different locations and any special event coming by. The IBC bank has the following operating hours you can check them out in the tables below. ADDRESS: 1000 Zaragoza St., Laredo, TX 78040.ADDRESS: 10700 McPherson Rd., Laredo, TX 78040 Get hours, reviews, customer service phone number and driving directions.ADDRESS: 1002 Matamoros St., Laredo, TX 78040.ADDRESS: 1300 Guadalupe St., Laredo, TX 78040.You can visit their contact page for all their customer service numbers. Whether you have a general question about your account or are looking for this bank’s routing number, they’ve got you covered. IBC Bank’s customer service can help you answer a variety of different questions relating to its bank. IBC Bank’s Customer Service Contact Information For lobby hours, drive-up hours and online banking services please visit the official website of the bank at. You can do so at email protected Here are the phone numbers for two of the main offices of the IBC Bank in Texas: IBC Laredo. You can also contact the bank by calling the branch phone number at 95 IBC Bank McAllen Main branch operates as a full service brick and mortar office. If you are already a customer of this bank then you do not have to pay any transaction fee. IBC Bank Customer Service, Phone Numbers and Support Resources (956) 722-7611. (CST), Monday through Friday and 8:00 a.m. In total, IBC Bank has plenty of ATMs available to choose from. General Customer Service (866) 952-9523 Espanol (855) 574-4183 Report an Unauthorized or Incorrect Transaction (855) 226-5828 Service hours are 7:00 a.m. 1-86 Lenexa, KS Distribution Center 11711 W 85th Street Lenexa, KS 66214 P 888-ICC-SAFE (88) and press 0 F (913) 888-4526 Palatine, IL S. 24-Hour ATMsĪlternatively, you can also use one of their many ATMs to deposit or withdraw cash 24/7. This option works best if you need to access your bank account or use their banking services outside of their normal business hours. Bank this way if their branches are closed outside of their normal hours from 9:00 a.m. IBC Bank offers both online and mobile banking. There are two main ways to access this bank outside of its regularly scheduled business hours. In Canada Call 1-80 Outside of Canada Call 1-90 You can also save a call and skip to most commonly asked questions. How To Bank With IBC Bank Outside Normal Business Hours Talk to our knowledgeable, trained staff at our Business Contact Centre, available Monday to Friday from 7:00 am to 10:00 pm ET. So the bank is closed the preceding Friday, December 31st, and the following Monday, December 26th. New Year’s Day and Christmas happen during a weekend in 2022. If you have any query regarding your bank account or the operating hours of your nearby branch, then you can contact the customer service desk of IBC bank by using the following information: Phone number: (956) 722-7611 Routing number: 114902528. *All IBC Bank’s are closed during holidays recognized by the Federal Reserve. Here are all the holidays they are closed on in 2022. IBC Bank follows a similar schedule to other banks for which holidays they close on. Here are IBC Bank’s hours on Saturday and Sunday: Day If you want to visit one of their locations, you will have to wait until they open back up Monday morning at 9:00 a.m. IBC Bank Weekday Schedule (Monday through Friday) Day Its typical weekday hours (Mon-Fri) are 9:00 a.m. Most branches are open five days a week, Monday through Friday. The majority of IBC Bank’s branches are not open 7 days a week. On top of that, alternative ways to use IBC Bank’s banking services are also provided. On Saturday and Sunday, their locations are closed.Īside from the weekday and weekend hours, below, you will also find its holiday bank schedule. On weekdays, Monday through Friday, they open at 9:00 a.m.Įven though on each of the five days, they open up at the same time. Since its origination in 1966, the bank has grown to accumulate over 215 branches and a good deal of ATMs available for its customers to use. IBC Bank has been around for over 56 years and has $11.8 billion in assets. ![]() Before the song was announced, Mizuki's seiyuu, Satou Hinata covered the song on MAGES' official channel, with Azusawa Kohane's and Shiraishi An's seiyuu, Akina and Sumi Tomomi Jiena, following suit on their respective channels. This is a list of original songs produced by the producer, EZFG. ![]() Wearing different clothes, I pretend to be a boy in front of you! He is introduced as the one who discovered and encouraged many fellow utaite to upload their first covers on NND, considering him as a got talent producer. The more cruel a town, the more beautiful its rainbowĭancing on obscene ads, it's a pop-font love This is a song dedicated to all the great villainsĪcting the part to the very bone, viciously / Totemo Itai Itagaritai CoverTaka Radjiman 32,034 views Premiered 3.8K Dislike Share Taka RadjimanNIJISANJI / 117K subscribers Support me on Streamlabs. Rotten Heresy and Chocolate w/lyrics (english, romaji, kanji) cover by Soraru. Duran Duran, please come pick me upĮven to people I don't know, I'm already a villain Fm B C Cm D Chords for Totemo Itai Itagaritai w/lyrics (english. ![]() Wearing different clothes, I pretend to be a boy in front of youĭear Dr. Crazy Villain Villain, like nocturnal petals They're saying that I'm "infringing" upon you Stubborn people hoard many goods and evils Totemo Itai Itagaraitai VY1 & VY2 mapped by alexandra a submitted last updated Sign In to access more features Graveyard 2:58 142 7 73 Description My first beatmap,please enjoy to playing note : btw, saya Fujoshi desu, add ya Source EZFG Genre Unspecified Language Unspecified Success Rate 56. You're reported when you opt out of the "rat race" I'm sure we freak them out just by holding hands ![]() Immune-mediated AEs occurred in 19 (18.4%) pts. Grade 3/4 treatment-related AEs occurred in 13 (12.6%) pts 1 death was considered treatment-related (colitis in patient inadequately treated with steroids). Treatment-related adverse events (AEs) occurred in 65 (63.1%) pts most frequent were pruritus (10.7%), fatigue (9.7%), diarrhea (8.7%), hypothyroidism (5.8%), and maculopapular rash (5.8%). 10 (25.0%) experienced recurrent NMIBC after CR at the time of analysis, none progressed to muscle invasive or metastatic disease. 80.2% of pts had a CR duration of ≥6 mo (Kaplan-Meier method). Among 40 pts who achieved CR at 3 mo, 72.5% maintained CR at last follow-up (median 14.0 mo range 4.0-26.3) and median CR duration has not been reached (range 0+ to 14.1+ mo). Results: 103 pts (median age 73 years CIS alone 71.8% median number of prior BCG instillations 12) have enrolled in cohort A. Primary end point: complete response rate (CRR) key secondary end points: duration of response and safety. Pts with HR NMIBC or progressive disease during treatment were required to discontinue. Methods: Pts with histologically confirmed HR, BCG-unresponsive CIS with or without papillary disease, who received adequate BCG therapy and were unable/unwilling to undergo radical cystectomy received pembro 200 mg Q3W for 24 mo or until recurrence, progression, or unacceptable toxicity. Efficacy and safety of pembro in pts with HR, BCG-unresponsive NMIBC was evaluated in the single-arm phase 2 KEYNOTE-057 study updated results for pts with carcinoma in situ (CIS) with or without papillary tumor (cohort A) are reported. Upregulation of the PD-1 pathway has been observed in BCG-resistant NMIBC, suggesting pembro may benefit. 384, 2102–2114 (2021).Background: The PD-1 inhibitor pembro has durable antitumor activity in pts with metastatic urothelial carcinoma. Adjuvant nivolumab versus placebo in muscle-invasive urothelial carcinoma. Therapy for stage IV non-small-cell lung cancer with driver alterations: ASCO and OH (CCO) joint guideline update. April 27-29, 2021: meeting of the Oncologic Drugs Advisory Committee meeting announcement. FDA alerts health care professionals and oncology clinical investigators about an efficacy issue identified in clinical trials for some patients taking Keytruda (pembrolizumab) or Tecentriq (atezolizumab) as monotherapy to treat urothelial cancer with low expression of PD-L1. Atezolizumab with or without chemotherapy in metastatic urothelial cancer (IMvigor130): a multicentre, randomised, placebo-controlled phase 3 trial. Pembrolizumab monotherapy for the treatment of high-risk non-muscle-invasive bladder cancer unresponsive to BCG (KEYNOTE-057): an open-label, single-arm, multicentre, phase 2 study. Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial. First-line pembrolizumab (pembro) in cisplatin-ineligible patients with advanced urothelial cancer (UC): response and survival results up to five years from the KEYNOTE-052 phase 2 study. First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study. Pembrolizumab as second-line therapy for advanced urothelial carcinoma. |